Review Article

HLA Epitopes: The Targets of Monoclonal and Alloantibodies Defined

Table 4

Cryptic (C) epitopes on dissociated class I HLA antigen—partial list. Complete list in supplemental file.

Epitope numberDissociated antigen(s)Epitope siteEpitope numberDissociated antigen(s)Epitope sitec

5006A3002(152R)5033Cw2(211T)
5007A31, A33(73I)5036Cw17(116F) + (143S)
5008A3401(63N) + (66K)5038Cw6(9D) + (97W)
5009A3402(63N) + (66K) + (156L)5039Cw7(66K) + (99S)
5010A80(31S)5049A6602(114Q) + 163E
5027B8(9D)5052B76(70N) + 166D
5031B82(24S) + (99F)

cAmino acids and their positions on the HLA-dissociated antigens define each epitope. In intact antigens, these amino acids are not exposed at the surface (cryptic).