Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models

Figure 1

Homing of cyclic RGD-liposomes to cervical lymph nodes and lungs in allergic asthmatic mice. Cyclic RGD- and DiR-labeled liposomes were injected intravenously into OVA-allergic BALB/c mice. (a, d) PBS-challenged; (b, e) OVA-challenged; (c, f) mannan pretreatment (1 mg, i.n., 30 min before each of the three OVA challenges). FRI images were acquired 2, 6, and 24 hr postinjection. The intensity of the signals in the cervical lymph nodes (c) and lungs (f) in SC-MN-pretreated mouse was markedly diminished compared to that in the OVA-challenged mouse (b, e). Signals in the lungs were detected at the 24 hr time point (d–f). The results are representative of 2 separate experiments with similar results.