Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models

Figure 7

Intranasal mannan blocked the OVA-induced increase in small airway smooth muscle as well as in cellular infiltration, in allergic transgenic mice. OVA-sensitized mice treated with SC-MN prior to OVA or PBS challenge. Representative sections show tissue morphology at day 45, visualized by H&E staining (midlevel left lung). (a) Saline + PBS (control); (b) saline + OVA; (c) SC-MN 45 mg/kg + OVA. Isoactin staining shows organized and thickened ASM in the OVA group (e) compared to the control (d) and SC-MN-treated mice (f). PAS staining shows magenta neutral mucin staining in OVA-sensitized and OVA-challenged mice (h).