Beneficial Effects of Prebiotic Saccharomyces cerevisiae Mannan on Allergic Asthma Mouse Models

Table 1

Effect of intranasally administered SC-MN on airway inflammation in WT BALB/c allergic mice.

Aerosol challenge	Total cell number/ml	Macrophages	Lymphocytes	Eosinophils	Neutrophils
PBS	326,000 ± 6000	245,000	55,000	9780	6520
OVA	530,000 ± 30,000	260,000	196,000	27,000	11,000
SC-MN + OVA	242,000 ± 18,000	138,980	96,960	4040	2020

Mice pretreated with SC-MN (i.n.) showed marked reduction in total BAL cell numbers compared to the OVA group. The decrease is also reflected in all four cell types analyzed. Results are mean ± SEM for total cell numbers in BALF and mean differential cell counts (). , OVA group versus PBS or SC-MN + OVA group.