Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6/lpr Mice

Figure 1

The genotyping results of β-cat^Tglpr/lpr mice. When mice was 4 weeks old, the genomic DNA was extracted and used for genotyping. (a) The representative genotyping results of β-cat^Tg and lpr/lpr mice. β-cat^Tg = 633 bp, β-cat^WT (WT) = 0 bp; Fas mutant (lpr/lpr) = 217 bp, Fas wild type (WT) = 179 bp, Fas heterozygote (Fas^+/−) = 217 bp and 179 bp. 1: β-cat^Tg (β-cat^Tg FAS^+/−) mice; 2: WT (β-cat^WT FAS^+/+) mice; and 3: β-cat^Tglpr/lpr mice. (b) The representative FACS results of β-cat^Tg mice, respectively, gating on CD3⁻ and CD3⁺ T cell. When the GFP⁺% of T cell is greater than 5%, the mouse is defined as β-cat^Tg mice.

(a)

(b)