Stabilized β-Catenin Ameliorates ALPS-Like Symptoms of B6/lpr Mice

Figure 3

Stabilized β-catenin slightly ameliorated the augments of splenic lymphocytes of lpr/lpr mice. All female animals were sacrificed at age 6 months, and splenocytes were isolated and stained with indicated surface markers. (a) The representative FACS results of CD4⁺ and CD8⁺ T cell subpopulation, gating on TCRβ positive cell. (b) Statistic analysis of the number of spleen cells, T cells, CD4⁺, CD8⁺, and DNT (TCRβ⁺CD4⁻CD8⁻) cells and the ratios of CD4 to CD8 in different genotype mice. Data are shown as mean ± SD (–10). ; ; and .

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