HLA Class Ia and Ib Polyreactive Anti-HLA-E IgG2a Monoclonal Antibodies (TFL-006 and TFL-007) Suppress Anti-HLA IgG Production by CD19+ B Cells and Proliferation of CD4+ T Cells While Upregulating Tregs

Figure 10

Different immunoregulatory roles attributed for the polyreactive polyclonal IVIg and proven functions of anti-HLA-E IgG2a monoclonal Abs. We have compared three functions of IVIg with that of anti-HLA-E IgG2a monoclonal Abs. We have monitored (1) suppression of CD19+ B lymphocyte blastogenesis, proliferation, and anti-HLA-I and anti-HLA-II IgG Abs, (2) suppression of blastogenesis and proliferation of CD4+ as well as CD8+ T lymphocytes, and (3) upregulation of blastogenesis and proliferation of Tregs. Our results indicate that the performance of anti-HLA-E mAbs TFL-006 and TFL-007 (the functions are recorded in red) is far superior to IVIg in achieving these functions [47, 48].