HLA Class Ia and Ib Polyreactive Anti-HLA-E IgG2a Monoclonal Antibodies (TFL-006 and TFL-007) Suppress Anti-HLA IgG Production by CD19+ B Cells and Proliferation of CD4+ T Cells While Upregulating Tregs

Figure 3

The anti-HLA-E mAb TFL-007s (conc. 5 μg/ml) but not IVIg (GamaStan, conc. 1.5 mg/ml) shows inhibition of the secondary allo-Ab anti-DRB11401 IgG. p² (two-tailed value). The details of experimental protocol are identical to those of Figure 2.