HLA Class Ia and Ib Polyreactive Anti-HLA-E IgG2a Monoclonal Antibodies (TFL-006 and TFL-007) Suppress Anti-HLA IgG Production by CD19+ B Cells and Proliferation of CD4+ T Cells While Upregulating Tregs

Table 1

Different therapeutic preparations of IVIg show extensive HLA-Ia and HLA-Ib reactivity, which is strikingly similar to the IgG2a monoclonal Abs developed in mice by immunizing with heavy chain of HLA-E^R [46, 47].

Different therapeutic preparations of IVIg versus different kinds of anti-HLA-E monoclonal antibodies	Reactivity of different HLA class I antigens
	Classical HLA-Ia alleles			Nonclassical HLA-Ib
	A	B	Cw	E	F	G
Maximum alleles tested	31	50	16	2	1	1
Therapeutic IVIg preparations
IVIg (GlobEx, India)	20	39	16	2	1	1
IVIg (GammaStan, USA)	31	50	16	2	1	1
IVIg (Octagam, Mexico)	30	47	16	2	1	1
IVIg (Sandaglobulin, Euro)	30	47	16	2	1	1
Anti-HLA-Ib antibodies
TFL-006 (IgG2a)	31	50	16	2	1	1
TFL-007 (IgG2a)	26	44	16	2	1	1
TFL-037 (IgG2b)	14	39	15	2	0	0
TFL-033 (IgG1)	0	0	0	2	0	0