LEAPS Vaccine Incorporating HER-2/neu Epitope Elicits Protection That Prevents and Limits Tumor Growth and Spread of Breast Cancer in a Mouse Model

Figure 1

J-HER prevention of TUBO cell tumor development. Mice were immunized with HBSS in Montanide ISA-51 adjuvant (orange rectangles) or J-HER in adjuvant (green circles), which was repeated 14 days later, and one week later, immunized mice () and unimmunized mice () were challenged with 2.5 × 10 [7] TUBO cells in each of two sites. Tumor volume is presented with respect to day after tumor challenge. Inset shows total tumor size for individual mice at day 48, end of experiment. (; ; ; .)