Continuous Dual Resetting of the Immune Repertoire as a Basic Principle of the Immune System Function

Figure 2

Compartmentalization: competent mucosal immune compartment is essential for appropriate function of the immune system. The CDR concept indicates favorable outcomes in a system with strong mucosal barrier function and appropriately sequestered systemic immune compartment (panel (a)). Panel (b) shows unfavorable outcomes in a system with deficient mucosal barrier function and poorly sequestered systemic immune compartment.

(a)

(b)