Novel Chemokine-Based Immunotoxins for Potent and Selective Targeting of Cytomegalovirus Infected Cells

Figure 5

Design, cell killing, and antiviral activity of an FTP with full domains of PE. (a) F49A-FTP-7 with full catalytic active domains of PE. (b) F49A-FTP-7 induced cell killing in comparison to F49A-FTP (dotted line) on tetracycline induced HEK-293 cells expressing US28 (black circles) and CX₃CR1 (white squares). (c) Inhibition of virus replication measured by luciferase activity of MRC-5 cells infected with (MOI 0,1) and treated once with F49A-FTP (dotted line) or FTPs from this group (black circles). Error bars indicate SEM for 2–5 independent biological replicates.

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