Difference in Antibody Responses to Mycobacterium tuberculosis Antigens in Japanese Tuberculosis Patients Infected with the Beijing/Non-Beijing Genotype
Table 4
Discriminatory power analysis.
TB antibodies
Cut
Sensitivity (%)
Specificity (%)
p value
TB subjects
Non-Beijing
Beijing
HC
Anti-Rv0679c142Asn IgG
0.09
83.1
93.3
75.0
45.8
0.0301
Anti-Rv0679c142Lys IgG
0.10
65.6
60.0
70.0
29.2
n.s.
Anti-Ag85B IgG
0.89
58.2
76.9
44.4
78.6
0.035
Anti-Ag85A IgG
0.76
42.0
46.2
38.9
92.9
0.0151
Anti-ACR IgG
0.21
48.2
30.8
61.1
78.6
0.0024
Anti-HBHA IgG
0.82
25.8
23.1
27.8
92.9
n.s.
Anti-TDM-M IgG
0.50
41.9
38.5
44.4
85.7
0.0025
Anti-TDM-K IgG
0.53
38.7
38.5
38.9
85.7
0.0031
Anti-MDPI IgG
0.40
67.8
69.2
66.7
14.3
n.s.
Anti-LAM IgG
0.76
67.7
66.7
68.4
83.3
<0.0001
Anti-TBGL IgG (U/mL)
55.6
62.5
50.0
100.0
0.0006
Anti-TBGL IgA (U/mL)
1.00
42.9
40.0
45.0
80.1
0.0008
Anti-TBGL IgG (U/mL) or anti-LAM IgG
—
76.5
80.0
73.7
83.3
—
Anti-TBGL IgG (U/mL) and anti-Ag85B IgG
—
35.6
53.8
22.2
100.0
—
Anti-ACR IgG or anti-TBGL IgA (U/mL)
—
59.4
40.0
75.0
64.3
—
The sensitivity of the test to discriminate between non-Beijing and Beijing genotype TB was calculated in the context of the cutoff values obtained for all TB subjects. A p value less than 0.05 indicates significant discriminatory power. cutoff was determined based on the ROC curve obtained for TB patients and healthy controls according to Youden’s index. to the recommended cutoff, in accordance with the instructions of the anti-TBGL IgG kit.
