TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
Table 2
Shared epitope frequency and HLA-DRB1 alleles frequency in Tunisian and French RA.
Alleles HLA-DRB1
Tunisian RA Allele number ( = 264)
Tunisian allele frequency (%)
French RA Allele number ( = 346)
French allele frequency (%)
OR [95% CI]
p value
p
#DRB01:XX
16
6.06
59
22.35
0.31 [0–0.51]
DRB01:03
0
0.00
1
0.38
0 [0–4.55]
0.32
NS
DRB03:XX
42
15.91
15
5.68
4.17 [2.48–+∞]
#DRB04:01
11
4.17
48
18.18
0.26 [0–0.47]
DRB04:02
1
0.38
1
0.38
1.31 [0.20–+∞]
0.39
NS
DRB04:03
3
1.14
4
1.52
0.98 [0–3.23]
0.51
NS
#DRB04:04
8
3.03
30
11.36
0.32 [0–0.64]
0.001
0.0022
#DRB04:05
19
7.20
12
4.55
2.15 [1.16–+∞]
0.01
NS
DRB04:06
6
2.27
0
0.00
+∞ [2.49–+∞]
0.002
0.044
DRB04:07
0
0.00
1
0.38
0 [0–4.56]
0.32
NS
#DRB04:08
3
1.14
9
3.41
0.43 [0–1.27]
0.11
NS
DRB04:11
1
0.38
0
0.00
+∞ [0.37–+∞]
0.18
NS
DRB07:XX
41
15.53
46
17.42
1.19 [0.81–+∞]
0.21
NS
DRB08:XX
3
1.14
1
0.38
3.96 [0.68–+∞]
0.11
NS
DRB09:XX
1
0.38
2
0.76
0.65 [0–3.98]
0.41
NS
#DRB10:01
33
12.50
13
4.92
3.65 [2.09–+∞]
DRB11:XX
19
7.20
25
9.47
0.99 [0–1.66]
0.5
NS
DRB12:XX
0
0.00
5
1.89
0 [0–0.83]
0.03
NS
DRB13:XX
40
15.15
24
9.09
2.39 [1.52–+∞]
0.0005
0.011
DRB14:XX
4
1.52
4
1.52
1.31 [0.43–+∞]
0.33
NS
DRB15:XX
12
4.55
33
12.50
0.45 [0–0.80]
0.009
NS
DRB16:XX
1
0.38
13
4.92
0.09 [0–0.49]
0.002
0.044
#Shared epitope, XX means all known alleles, DRB14: XX apart from DRB14:02 value corrected with Bonferroni correction. NS: not significant.
