TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin
Table 5
TMEM187-IRAK1 genotypes for samples of RA and healthy controls in Tunisian and French female populations.
Gene/SNPs
Population
Genotype
Controls (%)
RA cases (%)
OR (95% CI)
p values
TMEM 187 rs13397
Tunisian
GG
92 (70)
66 (53)
0.48 (0.12–0.73)
0.0025
AG
23 (18)
46 (41)
AA
16 (12)
7 (6)
French
GG
220 (65)
131 (45)
0.45 (0.21–0.59)
AG
97 (28)
137 (47)
AA
23 (7)
21 (8)
IRAK 1 rs1059703
Tunisian
CC
15 (11)
9 (7)
0.46 (0.13–0.71)
0.0017
CT
27 (21)
51 (43)
TT
89 (68)
59 (50)
French
CC
27 (8)
34 (12)
0.36 (0.15–0.47)
CT
85 (25)
133 (46)
TT
228 (67)
122 (42)
IRAK 1 rs1059702
Tunisian
CC
81 (62)
62 (52)
0.67 (0.18–1.02)
0.0608
CT
34 (26)
43 (36)
TT
16 (12)
14 (12)
French
CC
237 (70)
157 (54)
0.52 (0.24–0.68)
CT
83 (24)
100 (35)
TT
20 (6)
32 (11)
values compared genotypes according to the dominant/recessive model.
