TMEM187-IRAK1 Polymorphisms Associated with Rheumatoid Arthritis Susceptibility in Tunisian and French Female Populations: Influence of Geographic Origin

Table 7

Characteristics of all studies included in meta-analysis within the TMEM187-IRAK1 locus.

Study	Population	Group	Subjects	Women’s sex%	Average age in years	Genotype
						TMEM 187					IRAK 1					IRAK 1					IRAK 1
						rs13397					rs1059703					rs1059702					rs3027898
						GG	AG	AA	G	A	CC	CT	TT	C	T	CC	CT	TT	C	T	AA	AC	CC	A	C
This study	Tunisia	Case	119	100%	52.16 ± 13.61	66	46	7	178	60	9	51	59	69	169	62	43	14	167	71	—	—	—	—	—
		Control	131	100%	56.65 ± 17.37	92	23	16	207	55	15	27	89	57	205	81	34	16	196	66	—	—	—	—	—
This study	French	Case	289	100%	63.15 ± 20.71	131	137	21	399	179	34	133	122	201	377	157	100	32	414	164	—	—	—	—	—
		Control	340	100%	46.24 ± 8.92	220	97	23	537	143	27	85	228	139	541	237	83	20	557	123	—	—	—	—	—
Chatzikyriakidou et al. (2010)	Greece	Case	136	80%	60.8 ± 12.7	—	—	—	—	—	7	52	77	66	206	—	—	—	—	—	71	45	20	187	85
		Control	147	78%	56.23 ± 5.13	—	—	—	—	—	7	46	94	60	234	—	—	—	—	—	91	47	9	229	65
Han et al. (2013)	Korea	Case	1,318	100%	51.8 ± 12.2	—	—	—	—	—	715	389	59	1819	507	62	393	707	517	1807	719	383	56	1821	495
		Control	1,016	100%	36.7 ± 12.5	—	—	—	—	—	468	337	52	1273	441	59	336	465	454	1266	478	321	50	1277	421
Zhang et al. (2013)	China	Case	214	71%	54.63 (±15.77)	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	28	42	141	98	324
		Control	478	71%	54.84 (±10.45)	—	—	—	—	—	—	—	—	—	—	—	—	—	—	—	337	103	35	173	777