Review Article
The Role of Proteinase-Activated Receptors 1 and 2 in the Regulation of Periodontal Tissue Metabolism and Disease
Table 3
Biological effects of PAR2 activation in periodontal cells.
| | PAR2 | Periodontal destruction | Periodontal repair/protection |
| | Epithelial cells | ↑ IL-1α, IL-1β, IL-6, IL-8, TNFα [4, 47]
↑ MCP-1 [17]
↑ IL-33 [61] | ↑ β-defensin 2 [59] | | Fibroblasts | ↑ IL-8 [62] | | | Osteoblasts | ↑ RANKL [64] | ↓ RANKL [63]
↓ RANKL : osteoprotegerin ratio [63] | | Monocytic cells | ↑ IL-6, IL-8, MCP-1 [17] | |
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IL: interleukin; MCP: monocyte chemoattractant protein; RANKL: receptor activator of nuclear factor kappa-B ligand.
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