DEPTOR-mTOR Signaling Is Critical for Lipid Metabolism and Inflammation Homeostasis of Lymphocytes in Human PBMC Culture

Figure 5

Schematic representation explaining the network of DEPTOR, mTORC1, mTORC2, and lipogenesis/inflammation networks. DEPTOR is a natural inhibitor of mTORC1 pathway. Overexpression of mTORC1 inhibitor DEPTOR may partly reduce mTORC1 activity but may not decrease lipogenesis and inflammation. Addition of AKT inhibitors may decrease lipogenesis and inflammation in DEPTOR overexpressed cells. Moreover, DEPTOR knockdown may activate mTORC1 and increase lipogenesis and inflammation.