Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease

Figure 1

Comparison of PI3Kγ versus PI3Kδ inhibition on neutrophil functions. Novel inhibitors with >100-fold selectivity (versus other class 1 PI3K isoforms) for PI3Kγ (squares) or δ (circles) were compared across 3 neutrophil mechanisms. (a) Neutrophil chemotaxis to fMLP. (b) Neutrophil superoxide (SOX) generation following LPS priming and stimulation with fMLP. (c) Neutrophil degranulation (assessed via elastase release) following cytochalasin b priming and stimulation with fMLP. Mean ± standard error of experiments are plotted as % inhibition. pIC₅₀ (−logIC₅₀) values for both γ and δ inhibitors are indicated.

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