Targets of Neutrophil Influx and Weaponry: Therapeutic Opportunities for Chronic Obstructive Airway Disease

Figure 2

Summary illustration of neutrophil targets in chronic lung disease. Activation of NSPs during neutrophil maturation in the bone marrow is via DPP1. Chemotaxis to the lung can be modulated by targeting CXCR2 or PI3Kδ/γ, the latter of which can also inhibit SOX and NSP release.