Genetic Polymorphisms of Cytotoxic T-Lymphocyte Antigen 4 in Primary Biliary Cholangitis: A Meta-Analysis

Table 1

Basic characteristics of involved studies.

SNP	First author	Year	Race	Case					Control					P(HWE)
				A	B	AA	AB	BB	A	B	AA	AB	BB
rs231775	Kosh	2000	C	131	115	35	61	27	278	122	99	80	21	0.613
	Paulo	2003	C	69	31	23	23	4	88	46	29	30	8	0.955
	Fan	2004	A	46	108	6	37	34	139	181	23	93	44	0.021
	Yukiko	2006	A	30	60	5	20	20	61	85	14	33	26	0.545
	Eckart	2007	C	206	154	58	90	32	243	161	78	87	37	0.149
	Peter	2007	C	389	243	40	29	4	497	285	54	35	10	0.716
	Brian-3	2008	C	414	288	122	170	59	352	206	111	130	38	0.995
	Raoul	2008	C	313	203	95	123	40	407	165	145	118	23	0.883
	Brian-2	2008	C	421	281	131	161	59	258	152	79	99	27	0.644
	Erin	2009	C	545	417	162	223	96	1562	934	493	577	178	0.661
	Satoru	2010	A	226	390	42	143	123	224	312	47	131	90	0.955
	Yoshihiro	2011	A	314	586	55	204	191	313	429	66	181	124	0.997
	Mantaka	2012	C	144	56	52	40	8	226	90	81	64	13	<0.001
	Li	2013	A	180	444	20	140	152	312	438	49	214	112	0.001
rs231725	Brian-3	2008	C	442	260	139	164	48	391	167	137	117	25	0.998
	Satoru	2010	A	250	368	51	149	108	250	286	58	133	77	0.968
	Brian-1	2010	C	1091	641	368	357	141	1032	490	350	332	79	0.984
	Yoshihiro	2011	A	351	549	68	214	168	347	395	81	185	105	0.977
	Li	2013	A	204	420	29	146	137	316	434	59	198	118	0.109
rs3087243	Sabine	2005	C	167	141	40	87	27	170	162	49	72	45	0.089
	Peter	2007	C	222	168	59	104	32	301	251	82	137	57	0.987
	Brian-3	2008	C	407	295	118	171	62	318	240	91	136	52	0.925
	Brian-2	2008	C	400	302	117	168	66	234	176	70	94	41	0.358
	Erin	2009	C	602	360	198	205	78	1335	1161	362	613	273	0.656
	Satoru	2010	A	454	162	167	120	21	372	164	129	114	25	0.979
	Yoshihiro	2011	A	689	211	264	161	25	515	227	179	157	35	0.946
	Mantaka	2012	C	107	93	32	43	25	158	158	37	84	37	0.426
	Li	2013	A	430	194	159	112	41	492	258	170	152	53	0.048
rs5742909	Fan	2004	A	138	16	63	12	2	274	46	122	30	8	0.003
	Brian-3	2008	C	646	56	297	52	2	502	56	226	50	3	0.9
	Raoul	2008	C	477	39	220	36	2	509	63	226	56	4	0.803
	Erin	2009	C	852	110	377	99	5	2291	205	1055	183	10	0.509
	Satoru	2010	A	550	66	245	59	4	470	66	206	58	4	0.971
	Li	2013	A	541	83	246	49	17	644	106	288	68	19	<0.001

C: Caucasian; A: Asian; P(HWE): value of Hardy-Weinberg equilibrium for control.