Genetic Polymorphisms of Cytotoxic T-Lymphocyte Antigen 4 in Primary Biliary Cholangitis: A Meta-Analysis
Table 2
The results of heterogeneity.
SNP
Genetic model
I2 (%)
P(het)
Effect model
rs231775
G : A
54.1
0.008
Random
GG : AA
45.6
0.032
Random
GA : AA
0.0
0.616
Fixed
(GG + GA) : AA
31.9
0.121
Fixed
GG : (AA + GA)
37.3
0.079
Fixed
rs231725
A : G
0.0
0.674
Fixed
AA : GG
0.0
0.815
Fixed
GA : GG
6.9
0.368
Fixed
(AA + GA) : GG
20.2
0.286
Fixed
AA : (GG + GA)
0.0
0.858
Fixed
rs3087243
A : G
37.9
0.116
Fixed
AA : GG
11.8
0.337
Fixed
GA : GG
53.5
0.028
Random
(AA + GA) : GG
51.2
0.037
Random
AA : (GG + GA)
0.0
0.569
Fixed
rs5742909
T : C
69.4
0.001
Random
TT : CC
0.0
0.814
Fixed
TC : CC
66.7
0.01
Random
(TT + TC) : CC
69.0
0.007
Random
TT : (CC + TC)
0.0
0.864
Fixed
P(het): value of Q-test for heterogeneity test; : the proportion of total variation contributed among study variants; P(het) < 0.05 or I2 > 50% indicated significant heterogeneity, using a random model; otherwise, using a fixed model.
