Genetic Polymorphisms of Cytotoxic T-Lymphocyte Antigen 4 in Primary Biliary Cholangitis: A Meta-Analysis
Table 3
Results of CTLA4 polymorphisms and PBC.
SNP
Genetic model
Asian
Caucasian
Overall
OR
95%CI
OR
95%CI
OR
95%CI
rs231775
G : A
1.47
1.27, 1.72
<0.0001
1.24
1.09, 1.42
0.001
1.32
1.19, 1.47
<0.0001
GG : AA
2.10
1.55, 2.84
<0.0001
1.51
1.12, 2.04
0.006
1.72
1.37, 2.16
<0.0001
GA : AA
1.39
1.08, 1.79
0.011
1.24
1.09, 1.42
0.001
1.27
1.13, 1.43
<0.0001
(GG + GA) : AA
1.65
1.30, 2.10
<0.0001
1.31
1.16, 1.49
<0.0001
1.38
1.23, 1.54
<0.0001
GG : (AA + GA)
1.66
1.40, 1.96
<0.0001
1.39
1.18, 1.65
<0.0001
1.52
1.35, 1.71
<0.0001
rs231725
A : G
1.39
1.22, 1.57
<0.0001
1.27
1.12, 1.44
<0.0001
1.33
1.22, 1.45
<0.0001
AA : GG
1.92
1.47, 2.49
<0.0001
1.75
1.33, 2.29
<0.0001
1.83
1.52, 2.21
<0.0001
GA : GG
1.38
1.07, 1.76
0.012
1.11
0.93, 1.33
0.236
1.20
1.04, 1.38
0.015
(AA + GA) : GG
1.57
1.24, 1.99
<0.0001
1.23
1.04, 1.46
0.014
1.34
1.17, 1.53
<0.0001
AA: (GG + GA)
1.52
1.27, 1.83
<0.0001
1.66
1.29, 2.14
<0.0001
1.57
1.35, 1.82
<0.0001
rs3087243
A : G
0.78
0.68, 0.89
<0.0001
0.83
0.76, 0.91
<0.0001
0.81
0.75, 0.88
<0.0001
AA : GG
0.66
0.49, 0.90
0.008
0.70
0.58, 0.85
<0.0001
0.69
0.59, 0.81
<0.0001
GA : GG
0.76
0.63, 0.91
0.003
0.90
0.68, 1.21
0.491
0.84
0.70, 1.00
0.051
(AA + GA) : GG
0.74
0.62, 0.88
0.001
0.86
0.66, 1.11
0.250
0.80
0.68, 0.94
0.008
AA : (GG + GA)
0.74
0.55, 1.00
0.050
0.78
0.66, 0.92
0.004
0.77
0.67, 0.89
0.001
rs5742909
T : C
0.87
0.70, 1.08
0.206
0.92
0.55, 1.55
0.766
0.89
0.68, 1.17
0.417
TT : CC
0.90
0.51, 1.58
0.715
0.88
0.39, 1.99
0.762
0.89
0.56, 1.42
0.636
TC : CC
0.84
0.64, 1.10
0.199
0.95
0.55, 1.64
0.846
0.90
0.67, 1.22
0.506
(TT + TC) : CC
0.85
0.66, 1.09
0.200
0.93
0.53, 1.63
0.809
0.90
0.67, 1.20
0.463
TT : (CC + TC)
0.93
0.53, 1.63
0.804
0.87
0.39, 1.97
0.743
0.91
0.58, 1.45
0.695
OR: odd ratio; 95%CI: 95% confidence interval; p: value of Z-test for significance test of OR; using the Bonferroni correction, means statistically significant.
