Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma

Figure 2

Levels of ATP and P2X7R expression are significantly increased in the mouse model of neutrophilic asthma. (a) ATP levels analyzed by a luciferin-luciferase assay in the BALF. The values represent the means ± SEM (). compared with the PBS/OVA group. (b) P2X7R expression analyzed by with quantitative PCR in the lung tissue. The values represent the means ± SEM (). compared with the PBS/OVA group. (c) Positive correlation between the levels of ATP and neutrophils (, ) and (d) a relatively lower correlation between ATP and IL-17 levels (, ) in BALF from OVA plus LPS-sensitized mice. Data are the mean ± SEM; mice in each group.

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