Adenosine Triphosphate Promotes Allergen-Induced Airway Inflammation and Th17 Cell Polarization in Neutrophilic Asthma

Figure 6

Local administration of suramin suppresses the Th17 response. (a) Suramin decreased Th17 cytokine production after OVA challenge. BALFs were collected at 24 h after the last OVA challenge. The levels of IL-17A, IL-4, and IFN-γ in the BALF of mice from control, asthma, vehicle-treated, and suramin-treated groups were assessed by ELISAs. The values represent the means ± SEM (). and compared with the asthma group. (b) Suramin decreased Th17 cell counts in the lung. The percentages of Th17 cells among CD3⁺-gated lung cells from mice in control—A, asthma—B, vehicle-treated—C, and suramine-treated groups—D were analyzed by flow cytometry. Representative results are shown. (c) Histogram showing the absolute counts of Th17 cells among the lung cells of mice from the various groups. Values represent the means ± SEM. and compared with the asthma group.

(a)

(b)

(c)