Enavatuzumab, a Humanized Anti-TWEAK Receptor Monoclonal Antibody, Exerts Antitumor Activity through Attracting and Activating Innate Immune Effector Cells

Figure 7

Enavatuzumab treatment stimulates MCP-1 secretion in mouse xenograft models and in human cancer patients. (a) Mice bearing established A375 tumors were given a single dose of enavatuzumab or a control antibody. Human MCP-1 (left) and mouse MCP-1 (right) were measured by Luminex in the serum of 5 mice in each dosing group at the indicated times after treatment. Data from 5 mice are shown as median and interquartile range at each time point in the graph. (b) Patients were treated with enavatuzumab at 0.1 mg/kg (top) or 0.3 mg/kg (bottom) every two weeks, with dosing days indicated by the arrows above each graph. MCP-1 was measured in serum samples by Luminex. Each colored line represents data from one patient and patient (Pt) numbers are also listed.

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