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Journal of Immunology Research
Volume 2017 (2017), Article ID 5746031, 5 pages
Research Article

Chitinase-3-Like Protein 1 (YKL-40) Reflects the Severity of Symptoms in Atopic Dermatitis

Department of Dermatology, Venereology and Allergology, Wrocław Medical University, Wrocław, Poland

Correspondence should be addressed to Jacek C Szepietowski; lp.corw.demu@ikswoteipezs.kecaj

Received 14 February 2017; Revised 14 April 2017; Accepted 16 May 2017; Published 4 June 2017

Academic Editor: Mahboobeh Mahdavinia

Copyright © 2017 Joanna Salomon et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.


Chitinase-3-like protein 1 (YKL-40) is suggested to be associated with type 2 T helper response and atopy. The aim of the study was the evaluation of serum YKL-40 level in atopic dermatitis. The study was performed on 59 patients: 27 males and 32 females, aged from 18 to 64 years. The severity of the disease was assessed by the SCORAD and objective SCORAD indexes. The severity of pruritus was measured by the visual analogue scale. Blood samples were taken to examine serum level of YKL-40, total IgE level, C-reactive protein level, white blood cell count, and neutrophil count. YKL-40 serum levels were significantly higher in patients with atopic dermatitis compared to the controls. There was a positive correlation between YKL-40 concentration and SCORAD, objective SCORAD, and pruritus. This study has shown that YKL-40 serum level is increased in patients with atopic dermatitis and reflects the severity of symptoms.