Vaccinomics Approach for Designing Potential Peptide Vaccine by Targeting Shigella spp. Serine Protease Autotransporter Subfamily Protein SigA

Table 2

Epitopes for CD8⁺ T-cell along with their interacting MHC class I alleles with affinity < 250 nM.

Epitope	Interacting MHC-I allele (IC50) on the nM scale
VTARAGLGY	HLA-A∗29:02 (40.62), HLA-A∗01:01 (224.16), HLA-A∗30:02 (168.45), HLA-B∗15:02 (81.70), HLA-C∗03:03 (103.66)
FHTVTVNTL	HLA-B∗39:01 (9.02), HLA-B∗38:01 (62.10), HLA-B∗15:02 (21.84), HLA-C∗03:03 (5.48), HLA-C∗08:02 (211.91), HLA-C∗14:02 (92.18), HLA-C∗12:03 (78.92)
HTTWTLTGY	HLA-A∗26:01 (162.41), HLA-A∗25:01 (219.32), HLA-B∗15:02 (153.54), HLA-C∗14:02 (122.92), HLA-C∗12:03 (33.90), HLA-C∗03:03 (144.75)
IELAGTLTL	HLA-E∗01:01 (152.83), HLA-B∗40:01 (35.47), HLA-B∗15:02 (55.75), HLA-C∗03:03 (29.28), HLA-C∗12:03 (109.70)
IASFSQPDW	HLA-B∗58:01 (9.34), HLA-B∗57:01 (42.06), HLA-B∗53:01 (61.22), HLA-C∗03:03 (2.35), HLA-C∗08:02 (187.57), HLA-C∗15:02 (164.60), HLA-C∗12:03 (11.95), HLA-C∗14:02 (248.10)
ARAGLGYQF	HLA-C∗12:03, HLA-C∗03:03 (53.53), HLA-B∗15:02 (107.95), HLA-B∗27:05 (97.18)
NYAWVNGNI	HLA-A∗68:02 (188.19), HLA-C∗14:02 (21.26), HLA-C∗03:03 (220.60), HLA-C∗12:03 (60.56)
KSYMSGNYK	HLA-C∗15:02 (6.94), HLA-A∗30:01 (9.18), HLA-A∗11:01 (11.28), HLA-A∗03:01 (20.22), HLA-A∗31:01 (54.63), HLA-C∗14:02 (40.80), HLA-C∗03:03 (61.75), HLA-C∗12:03 (31.71)
YMSGNYKAF	HLA-B∗15:01 (61.09), HLA-B∗35:01 (124.62), HLA-C∗14:02 (17.24), HLA-B∗15:02 (61.69), HLA-C∗03:03 (13.14), HLA-C∗12:03 (151.43)
SMYNTLWRV	HLA-A∗02:01 (6.70), HLA-A∗02:06 (13.79), HLA-C∗14:02 (105.59), HLA-C∗12:03 (30.21)
APKGSNKEI	HLA-B∗07:02 (199.48), HLA-C∗12:03 (7.82), HLA-C∗03:03 (37.81)