Research Article

Synergistic Effects of Cabozantinib and EGFR-Specific CAR-NK-92 Cells in Renal Cell Carcinoma

Figure 7

Treatment with cabozantinib increases the sensitivity of renal cancer cells to the CAR-NK-92 cell-mediated killing.786-O and ACHN cells were treated with 2.5 μg/ml cabozantinib or vehicle for 24 h, then coincubated with the CAR-NK-92 cells for 4 h. The cytotoxic activity of CAR-NK-92 cells was determined by LDH release assay. ; ; . ns: not significant.