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Journal of Immunology Research
Volume 2017, Article ID 7047201, 11 pages
https://doi.org/10.1155/2017/7047201
Research Article

Th1/Th2 Balance and Th17/Treg-Mediated Immunity in relation to Murine Resistance to Dextran Sulfate-Induced Colitis

1Department of Immunology, China Medical University, Shenyang 110122, China
2Department of Immunology, College of Basic Medical Sciences, Shenyang Medical College, Shenyang 110034, China

Correspondence should be addressed to Changlong Lu; moc.qq@502392268

Received 16 November 2016; Accepted 9 March 2017; Published 11 May 2017

Academic Editor: Kurt Blaser

Copyright © 2017 Fangli Yang et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. L. J. Dixon, A. Kabi, K. P. Nickerson, and C. McDonald, “Combinatorial effects of diet and genetics on inflammatory bowel disease pathogenesis,” Inflammatory Bowel Diseases, vol. 21, no. 4, pp. 912–922, 2015. View at Publisher · View at Google Scholar · View at Scopus
  2. R. J. Xavier and D. K. Podolsky, “Unravelling the pathogenesis of inflammatory bowel disease,” Nature, vol. 448, no. 7152, pp. 427–434, 2007. View at Publisher · View at Google Scholar · View at Scopus
  3. G. Latella and C. Papi, “Crucial steps in the natural history of inflammatory bowel disease,” World Journal of Gastroenterology: WJG, vol. 18, no. 29, pp. 3790–3799, 2012. View at Publisher · View at Google Scholar · View at Scopus
  4. G. Hundorfean, M. F. Neurath, and J. Mudter, “Functional relevance of T helper 17 (Th17) cells and the IL-17 cytokine family in inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 18, no. 1, pp. 180–186, 2012. View at Publisher · View at Google Scholar · View at Scopus
  5. I. C. Roberts-Thomson, J. Fon, W. Uylaki, A. G. Cummins, and S. Barry, “Cells, cytokines and inflammatory bowel disease: a clinical perspective,” Expert Review of Gastroenterology & Hepatology, vol. 5, no. 6, pp. 703–716, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. A. Geremia and D. P. Jewell, “The IL-23/IL-17 pathway in inflammatory bowel disease,” Expert Review of Gastroenterology & Hepatology, vol. 6, no. 2, pp. 223–237, 2012. View at Publisher · View at Google Scholar · View at Scopus
  7. C. Wang, S. G. Kang, J. Lee, Z. Sun, and C. H. Kim, “The roles of CCR6 in migration of Th17 cells and regulation of effector T-cell balance in the gut,” Mucosal Immunology, vol. 2, no. 2, pp. 173–183, 2009. View at Publisher · View at Google Scholar · View at Scopus
  8. I. I. Ivanov, B. S. McKenzie, L. Zhou et al., “The orphan nuclear receptor RORgammat directs the differentiation program of proinflammatory IL-17+ T helper cells,” Cell, vol. 126, no. 6, pp. 1121–1133, 2006. View at Publisher · View at Google Scholar · View at Scopus
  9. C. Zaph, Y. Du, S. A. Saenz et al., “Commensal-dependent expression of IL-25 regulates the IL-23-IL-17 axis in the intestine,” The Journal of Experimental Medicine, vol. 205, no. 10, pp. 2191–2198, 2008. View at Publisher · View at Google Scholar · View at Scopus
  10. I. I. Ivanov, L. Frutos Rde, N. Manel et al., “Specific microbiota direct the differentiation of IL-17-producing T-helper cells in the mucosa of the small intestine,” Cell Host & Microbe, vol. 4, no. 4, pp. 337–349, 2008. View at Publisher · View at Google Scholar · View at Scopus
  11. G. Fonseca-Camarillo, E. Mendivil-Rangel, J. Furuzawa-Carballeda, and J. K. Yamamoto-Furusho, “Interleukin 17 gene and protein expression are increased in patients with ulcerative colitis,” Inflammatory Bowel Diseases, vol. 17, no. 10, pp. E135–E136, 2011. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Dambacher, F. Beigel, K. Zitzmann et al., “The role of the novel Th17 cytokine IL-26 in intestinal inflammation,” Gut, vol. 58, no. 9, pp. 1207–1217, 2009. View at Publisher · View at Google Scholar · View at Scopus
  13. A. Visperas, J. S. Do, K. Bulek, X. Li, and B. Min, “IL-27, targeting antigen-presenting cells, promotes Th17 differentiation and colitis in mice,” Mucosal Immunology, vol. 7, no. 3, pp. 625–633, 2014. View at Publisher · View at Google Scholar · View at Scopus
  14. C. G. Mayne and C. B. Williams, “Induced and natural regulatory T cells in the development of inflammatory bowel disease,” Inflammatory Bowel Diseases, vol. 19, no. 8, pp. 1772–1788, 2013. View at Publisher · View at Google Scholar · View at Scopus
  15. M. Mahler, I. J. Bristol, E. H. Leiter et al., “Differential susceptibility of inbred mouse strains to dextran sulfate sodium-induced colitis,” The American Journal of Physiology, vol. 274, no. 3 Pt 1, pp. G544–G551, 1998. View at Google Scholar
  16. M. Aguilera, T. Darby, and S. Melgar, “The complex role of inflammasomes in the pathogenesis of inflammatory bowel diseases - lessons learned from experimental models,” Cytokine & Growth Factor Reviews, vol. 25, no. 6, pp. 715–730, 2014. View at Publisher · View at Google Scholar · View at Scopus
  17. C. Kilkenny, W. J. Browne, I. C. Cuthill, M. Emerson, and D. G. Altman, “Improving bioscience research reporting: the ARRIVE guidelines for reporting animal research,” PLoS Biology, vol. 8, no. 6, Article ID e1000412, 2010. View at Publisher · View at Google Scholar · View at Scopus
  18. H. S. Cooper, S. N. Murthy, R. S. Shah, and D. J. Sedergran, “Clinicopathologic study of dextran sulfate sodium experimental murine colitis,” Laboratory Investigation, vol. 69, no. 2, pp. 238–249, 1993. View at Google Scholar
  19. X. Sun, S. Somada, K. Shibata et al., “A critical role of CD30 ligand/CD30 in controlling inflammatory bowel diseases in mice,” Gastroenterology, vol. 134, no. 2, pp. 447–458, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. J. Zhu, F. Yang, L. Sang et al., “IL-33 aggravates DSS-induced acute colitis in mouse colon lamina propria by enhancing Th2 cell responses,” Mediators of Inflammation, vol. 2015, p. 913041, 2015. View at Publisher · View at Google Scholar · View at Scopus
  21. T. Tsuchiya, S. Fukuda, H. Hamada et al., “Role of gamma delta T cells in the inflammatory response of experimental colitis mice,” Journal of Immunology, vol. 171, no. 10, pp. 5507–5513, 2003. View at Publisher · View at Google Scholar
  22. A. Y. Lee, R. Eri, A. B. Lyons, M. C. Grimm, and H. Korner, “CC chemokine ligand 20 and its cognate receptor CCR6 in mucosal T cell immunology and inflammatory bowel disease: odd couple or axis of evil?” Frontiers in Immunology, vol. 4, p. 194, 2013. View at Publisher · View at Google Scholar · View at Scopus
  23. Y. L. Jones-Hall and M. B. Grisham, “Immunopathological characterization of selected mouse models of inflammatory bowel disease: comparison to human disease,” Pathophysiology, vol. 21, no. 4, pp. 267–288, 2014. View at Publisher · View at Google Scholar · View at Scopus
  24. B. Egger, M. Bajaj-Elliott, T. T. MacDonald, R. Inglin, V. E. Eysselein, and M. W. Buchler, “Characterisation of acute murine dextran sodium sulphate colitis: cytokine profile and dose dependency,” Digestion, vol. 62, no. 4, pp. 240–248, 2000. View at Publisher · View at Google Scholar
  25. G. X. Song-Zhao and K. J. Maloy, “Experimental mouse models of T cell-dependent inflammatory bowel disease,” Methods in Molecular Biology, vol. 1193, pp. 199–211, 2014. View at Publisher · View at Google Scholar · View at Scopus
  26. S. Melgar, A. Karlsson, and E. Michaelsson, “Acute colitis induced by dextran sulfate sodium progresses to chronicity in C57BL/6 but not in BALB/c mice: correlation between symptoms and inflammation,” American Journal of Physiology. Gastrointestinal and Liver Physiology, vol. 288, no. 6, pp. G1328–G1338, 2005. View at Publisher · View at Google Scholar · View at Scopus
  27. L. Camoglio, A. A. te Velde, A. de Boer, F. J. ten Kate, M. Kopf, and S. J. van Deventer, “Hapten-induced colitis associated with maintained Th1 and inflammatory responses in IFN-gamma receptor-deficient mice,” European Journal of Immunology, vol. 30, no. 5, pp. 1486–1495, 2000. View at Publisher · View at Google Scholar
  28. W. Wang, L. Xu, J. H. Brandsma et al., “Convergent transcription of interferon-stimulated genes by TNF-alpha and IFN-alpha augments antiviral activity against HCV and HEV,” Scientific Reports, vol. 6, p. 25482, 2016. View at Publisher · View at Google Scholar · View at Scopus
  29. W. Hans, J. Scholmerich, V. Gross, and W. Falk, “Interleukin-12 induced interferon-gamma increases inflammation in acute dextran sulfate sodium induced colitis in mice,” European Cytokine Network, vol. 11, no. 1, pp. 67–74, 2000. View at Google Scholar
  30. H. S. Kim and D. H. Chung, “IL-9-producing invariant NKT cells protect against DSS-induced colitis in an IL-4-dependent manner,” Mucosal Immunology, vol. 6, no. 2, pp. 347–357, 2013. View at Publisher · View at Google Scholar · View at Scopus
  31. W. Jiang, J. Su, X. Zhang et al., “Elevated levels of Th17 cells and Th17-related cytokines are associated with disease activity in patients with inflammatory bowel disease,” Inflammation Research, vol. 63, no. 11, pp. 943–950, 2014. View at Publisher · View at Google Scholar · View at Scopus
  32. T. Korn, E. Bettelli, M. Oukka, and V. K. Kuchroo, “IL-17 and Th17 cells,” Annual Review of Immunology, vol. 27, no. 1, pp. 485–517, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. Y. Iwakura, H. Ishigame, S. Saijo, and S. Nakae, “Functional specialization of interleukin-17 family members,” Immunity, vol. 34, no. 2, pp. 149–162, 2011. View at Publisher · View at Google Scholar · View at Scopus
  34. A. Ogawa, A. Andoh, Y. Araki, T. Bamba, and Y. Fujiyama, “Neutralization of interleukin-17 aggravates dextran sulfate sodium-induced colitis in mice,” Clinical Immunology, vol. 110, no. 1, pp. 55–62, 2004. View at Publisher · View at Google Scholar · View at Scopus
  35. D. Yen, J. Cheung, H. Scheerens et al., “IL-23 is essential for T cell-mediated colitis and promotes inflammation via IL-17 and IL-6,” The Journal of Clinical Investigation, vol. 116, no. 5, pp. 1310–1316, 2006. View at Publisher · View at Google Scholar · View at Scopus
  36. W. O'Connor Jr., M. Kamanaka, C. J. Booth et al., “A protective function for interleukin 17A in T cell-mediated intestinal inflammation,” Nature Immunology, vol. 10, no. 6, pp. 603–609, 2009. View at Publisher · View at Google Scholar · View at Scopus
  37. A. Mizoguchi, “Healing of intestinal inflammation by IL-22,” Inflammatory Bowel Diseases, vol. 18, no. 9, pp. 1777–1784, 2012. View at Publisher · View at Google Scholar · View at Scopus
  38. L. A. Zenewicz, G. D. Yancopoulos, D. M. Valenzuela, A. J. Murphy, S. Stevens, and R. A. Flavell, “Innate and adaptive interleukin-22 protects mice from inflammatory bowel disease,” Immunity, vol. 29, no. 6, pp. 947–957, 2008. View at Publisher · View at Google Scholar · View at Scopus
  39. G. M. Fuhler, K. Parikh, C. J. van der Woude, and M. P. Peppelenbosch, “Linkage between genotype and immunological phenotype in Crohn’s disease,” Annals of Translational Medicine, vol. 3, no. 16, p. 237, 2015. View at Publisher · View at Google Scholar
  40. P. Pelczar, M. Witkowski, L. G. Perez et al., “A pathogenic role for T cell-derived IL-22BP in inflammatory bowel disease,” Science (New York, N.Y.), vol. 354, no. 6310, pp. 358–362, 2016. View at Publisher · View at Google Scholar · View at Scopus
  41. O. Yoshie and K. Matsushima, “CCR4 and its ligands: from bench to bedside,” International Immunology, vol. 27, no. 1, pp. 11–20, 2015. View at Publisher · View at Google Scholar · View at Scopus
  42. A. Iellem, M. Mariani, R. Lang et al., “Unique chemotactic response profile and specific expression of chemokine receptors CCR4 and CCR8 by CD4(+)CD25(+) regulatory T cells,” The Journal of Experimental Medicine, vol. 194, no. 6, pp. 847–853, 2001. View at Publisher · View at Google Scholar · View at Scopus