Elevated Levels of Interferon-γ Are Associated with High Levels of Epstein-Barr Virus Reactivation in Patients with the Intestinal Type of Gastric Cancer

Table 1

Description of the study population and association of EBV antibody titers with GC.

Variable	Healthy controls^a	Gastric cancer
		Intestinal		Diffuse		Mixed		Total gastric cancer
Number studied (%)	118 (100)	40 (31.5)		63 (49.6)		24 (18.9)		127 (100)
Age (mean ± S.D.)^b	34.6 ± 11.3	67.1 ± 12.3		57.7 ± 13.2		63.7 ± 13.3		61.8 ± 13.5
Sex, male/female ratio	48/70 = 0.68	23/17 = 1.4		38/25 = 1.5		12/12 = 1		73/54 1.35
VCA-IgG titer^c,d (median) range	74.1 (23.5-150.4)	90.5^e (24.9–148)		73.5 (25.2–179)		82.3 (35.9–141.6)		76.0 (24.9–179)
VCA-IgG titer^c	n	n	OR (95% CI)	n	OR (95% CI)	n	OR (95% CI)	n	OR (95% CI)
23.5–60.5	39	9	1.0	22	1.0	6	1.0	37	1.0
60.6–83.2	40	10	1.2 (0.3–5.3)	16	0.9 (0.4–2.6)	6	1.9 (0.4–9.3)	32	1.0 (0.4–2.5)
83.3–150.7	39	21	3.0 (0.7–12.6)	25	0.6 (0.2–1.9)	12	3.2 (0.7–15.7)	58	0.8 (0.3–2.2)
p for trend			0.047		0.714		0.176		0.122

^aPopulation included for the analysis of IL-8, IFN-γ, and TGF-β. ^bStudent’s t-test. ^cHU·ml⁻¹. ^dOnly positive values were considered. . , .