The Role of Type III Interferons in Hepatitis C Virus Infection and Therapy

Figure 4

Schematic representation of the IFNL chromosome locus. Depicted is the position and orientation of the genes for IFNL1–4 (blue) on chromosome 19 q13 (green). The numbers below the genes display the nucleotide position of the first exon of each IFNL subtype. IFNL1-2 are located on the forward strand of the chromosome, while IFNL3-4 are located on the reverse strand. The genetic organization of IFNL4 is shown in more detail; it consists of five exons (blue) and 3′/5′ untranslated regions (UTR). Single nucleotide polymorphisms rs12979860, rs368234815, and rs8099917 and their corresponding nucleotide position are indicated (red). Adapted from [38, 39].