Passive Immunoprophylaxis for the Protection of the Mother and Her Baby: Insights from In Vivo Models of Antibody Transport

Figure 4

Fetal : maternal concentration ratio for total human IgG (a) and IgG subclasses (b) following hepatitis B immune globulin (HBIG) administration at different gestation ages. HBIG was administered intravenously at a dose of 100 IU/kg (~7 mg/kg) in pregnant guinea pigs at different gestation ages (GD, -axis). Fetal : maternal concentration ratios (shown as mean ± SEM) for the total IgG and IgG subclasses 1–3 increase exponentially with gestation age. Shown time points roughly correspond to the end of first trimester (GD26), middle and end of second trimester (GD35 and 45), and middle and end of third trimester (GD55 and 65). One- and two-way ANOVA with Bonferroni post hoc analyses were used to compare total human IgG and human IgG subclasses fetal : maternal concentration ratios in each gestation age; , , and .

(a)

(b)