Passive Immunoprophylaxis for the Protection of the Mother and Her Baby: Insights from In Vivo Models of Antibody Transport

Table 1

Pharmacokinetic (PK) parameters of a hepatitis B immune globulin (HBIG) product in pregnant and nonpregnant guinea pigs.

PK parameters (Mean ± SD)	3.5 mg/kg dose		7.0 mg/kg dose
	Control ()	Pregnant ()	Control ()	Pregnant ()
AUC (µghr/mL)	8690 ± 2418	3563 ± 2500	12522 ± 3309	8100 ± 2393
CL (mL/hr per kg)	0.4 ± 0.2	1.4 ± 0.9	0.6 ± 0.2	1 ± 0.4
Half-life (hours)	107 ± 24	108 ± 40	114 ± 58	60 ± 23
MRT (hours)	53 ± 4	35 ± 15	46 ± 4	35 ± 14
(mL/kg)	23 ± 9	41 ± 11	27 ± 6	30 ± 5

AUC: area under the curve; CL: clearance; MRT: mean residence time; : volume of distribution at steady state.