Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation

Figure 2

Subfamilies and the extracellular structure of human TLRs. (a) Human TLRs are divided into three phylogenetic subfamilies shown with different colors. The number and cellular location of amino acid residues are shown in the middle and right columns, respectively. (b) Computational modeling of the ectodomain structure of dimerized TLR7. Blue color shows the horseshoe-shaped solenoid structure of TLR ectodomain. Arrowheads indicate undefined regions (red color).

(a)

(b)