Natural Modulators of Endosomal Toll-Like Receptor-Mediated Psoriatic Skin Inflammation

Figure 3

The role of endosomal TLRs in the development of psoriasis and the mechanism of action of biological drugs. Endosomal TLRs in plasmacytoid dendritic cells (pDCs) and myeloid dendritic cells (mDCs) can be triggered by self-DNA and self-RNA that forms complexes with LL37 upon its release from necrotic cells. Cytokines released by DCs further drive T cell-mediated inflammation by activating cytokines that promote leukocyte recruitment and keratinocyte activation and proliferation. Blue font: biological drugs inhibit effector cytokines in psoriatic inflammation.