Figure 1: Amino acid sequence alignment of human C5a receptors. C5aR1 (top) and C5aR2 (bottom) were aligned using Praline (developed in the Centre for Integrative Bioinformatics Vrije Universteit Amsterdam). Transmembrane (TM) domains as well as intracellular (IC) and extracellular (EC) loops are indicated. Amino acid conservation is in the numeric representation. Regions important for G protein coupling in GPCRs are annotated as (DRY region) and (NPXXY region). Numbers at the right indicate the residue number.