Review Article
The Controversial C5a Receptor C5aR2: Its Role in Health and Disease
Table 1
C5aR2 KO on BALB/c background.
| Source | Disease model | Properties of C5aR2 | Refs |
| J. Khöl’s laboratories, University of Lübeck, Germany | OVA- and HDM-induced experimental allergic asthma | Dual functions: anti-inflammation on mDCs, proinflammation on pulmonary cells | [65] | TLR induction in vitro and in vivo | Dual functions: anti-inflammation—C5aR2 negatively modulates TLRs-C5aR1 on PBMCs and whole blood cells; proinflammation—C5aR2 promotes HMGB1 expression | [86] | Peritoneal membrane fibrosis | No function | [123] | TL31 KO from Amgen, South San Francisco | DSS-induced acute colitis | Proinflammation | [67] | Lexicon Genetics, the Woodlands, Texas | OVA-sensitized, methacholine-induced asthma | Proinflammation | [68] | Dr. Craig Gerard, Harvard Medical School—C57BL/6 mice backcrossed to the BALB/c background | OX-induced experimental allergic contact dermatitis | Anti-inflammation | [56] | LPS-induced acute lung injury | Anti-inflammation | [74] |
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