The Controversial C5a Receptor C5aR2: Its Role in Health and Disease

Table 1

C5aR2 KO on BALB/c background.

Source	Disease model	Properties of C5aR2	Refs
J. Khöl’s laboratories, University of Lübeck, Germany	OVA- and HDM-induced experimental allergic asthma	Dual functions: anti-inflammation on mDCs,; proinflammation on pulmonary cells	[65]
	TLR induction in vitro and in vivo	Dual functions: anti-inflammation—C5aR2 negatively modulates TLRs-C5aR1 on PBMCs and whole blood cells; proinflammation—C5aR2 promotes HMGB1 expression	[86]
	Peritoneal membrane fibrosis	No function	[123]
TL31 KO from Amgen, South San Francisco	DSS-induced acute colitis	Proinflammation	[67]
Lexicon Genetics, the Woodlands, Texas	OVA-sensitized, methacholine-induced asthma	Proinflammation	[68]
Dr. Craig Gerard, Harvard Medical School—C57BL/6 mice backcrossed to the BALB/c background	OX-induced experimental allergic contact dermatitis	Anti-inflammation	[56]
	LPS-induced acute lung injury	Anti-inflammation	[74]