The Controversial C5a Receptor C5aR2: Its Role in Health and Disease

Table 3

C5aR2 KO with lipometabolism.

Source	Disease model	Properties of C5aR2	Refs
C5aR2 heterozygous mice from Regeneron Pharmaceutics Inc.	Physiological metabolism of C5aR2 KO mice	Stimulates TG synthesis and glucose transport in adipose tissue	[106]
	Diet induced obesity	Anti-inflammation	[95, 113]
	Partial hepatectomy	Promotes liver regeneration	[97]
	High fat diet-induced insulin resistance	Anti-inflammation, metabolic regulation	[112]