The Controversial C5a Receptor C5aR2: Its Role in Health and Disease

Table 4

C5aR2 agonists and antagonists.

Ligand	Specificity	Function	Refs
Jun/fos-A8; Jun/fos-A8^△71–73; C5 mutant peptides	Human and murine C5aR1 and C5aR2	Antagonists—block binding of C5a and C5a; des Arg to C5aRs	[51]
P32, P59—C terminal peptides; of C5a	hC5aR2	Agonists—strongly stimulate the association of; hC5aR2 with β-arrestin 2	[21, 127]
LukS-PV—protein from S. aureus	Human and rabbit C5aR1; Human, macaque, and rabbit C5aR2	Antagonist of C5a-induced activation of neutrophils	[48, 128]
HIgCB—protein complex from; S. aureus	Human, macaque, rabbit, and cow C5aRs	Antagonist of C5a-induced activation of neutrophils	[128, 129]