Table 4: C5aR2 agonists and antagonists.

LigandSpecificityFunctionRefs

Jun/fos-A8
Jun/fos-A8△71–73
C5 mutant peptides
Human and murine C5aR1 and C5aR2Antagonists—block binding of C5a and C5a
des Arg to C5aRs
[51]
P32, P59—C terminal peptides
of C5a
hC5aR2Agonists—strongly stimulate the association of
hC5aR2 with β-arrestin 2
[21, 127]
LukS-PV—protein from S. aureusHuman and rabbit C5aR1
Human, macaque, and rabbit C5aR2
Antagonist of C5a-induced activation of neutrophils[48, 128]
HIgCB—protein complex from
S. aureus
Human, macaque, rabbit, and cow C5aRsAntagonist of C5a-induced activation of neutrophils[128, 129]