Mahuang Fuzi Xixin Decoction Attenuates Th1 and Th2 Responses in the Treatment of Ovalbumin-Induced Allergic Inflammation in a Rat Model of Allergic Rhinitis

Figure 1

Schematic diagram of preparation of AR model rats and MFXD administration. Rats were intraperitoneally sensitized with OVA and Al(OH)₃ dissolved in physiological saline once every other day for 2 weeks and then challenged through nasal instillation with 5% OVA into each nasal cavity once daily from day 15 to day 21. Rats in MFXD, loratadine, and model groups were orally administered with three doses of MFXD, loratadine solution, and water once daily from day 22 to day 31, respectively, and were nasally instilled with OVA solution once every other day to maintain the nasal stimulation. Rats in the control group were sensitized with Al(OH)₃, challenged with saline, and orally administered with water. All the rats were sacrificed on day 31.