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Journal of Immunology Research
Volume 2017 (2017), Article ID 8539294, 9 pages
https://doi.org/10.1155/2017/8539294
Research Article

The Expression of IL-6, TNF-α, and MCP-1 in Respiratory Viral Infection in Acute Exacerbations of Chronic Obstructive Pulmonary Disease

1Departments of Pathogenic Biology, College of Basic Medical Sciences, Jilin university, Changchun, China
2School of Pharmaceutical Sciences, Jilin University, Jilin, China
3Department of Respiratory Disease, Jilin Provincial People’s Hospital, Changchun, China
4Department of Disease Control and Prevention, Beijing Shunyi District Center, Beijing, China
5Department of Respiratory and Sleep Medicine, John Hunter Hospital, Newcastle, NSW, Australia
6Department of Respiratory and Sleep Medicine, University of Newcastle, New Lambton, NSW, Australia
7Department of Intensive Care Unit, First Hospital of Jilin University, Changchun 130021, China
8Department of Clinical Laboratory, The Second Hospital of Jilin University, Changchun 130021, China

Correspondence should be addressed to Fang Wang; nc.ude.ulj@fw

Received 23 September 2016; Revised 4 January 2017; Accepted 9 February 2017; Published 2 March 2017

Academic Editor: Andréia M. Cardoso

Copyright © 2017 Jingtong Zheng et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

Linked References

  1. R. Rodriguez-Roisin, “Toward a consensus definition for COPD exacerbations,” Chest, vol. 117, no. 5, pp. 398–401, 2000. View at Google Scholar · View at Scopus
  2. Global Initiative for Chronic Obstructive Lung Disease (GOLD), “Global strategy for the diagnosis, management of chronic obstructive pulmonary disease,” NHLBI/WHO Workshop Report, 2006, http://goldcopd.org/global-strategy-diagnosis-management-prevention-copd-2016/. View at Google Scholar
  3. G. Rohde, A. Wiethege, I. Borg et al., “Respiratory viruses in exacerbations of chronic obstructive pulmonary disease requiring hospitalisation: a case-control study,” Thorax, vol. 58, no. 1, pp. 37–42, 2003. View at Publisher · View at Google Scholar · View at Scopus
  4. S. S. Weigt, A. L. Gregson, J. C. Deng, J. P. Lynch, and J. A. Belperio, “Respiratory viral infections in hematopoietic stem cell and solid organ transplant recipients,” Seminars in Respiratory and Critical Care Medicine, vol. 32, no. 4, pp. 471–493, 2011. View at Publisher · View at Google Scholar · View at Scopus
  5. C. Renaud and A. P. Campbell, “Changing epidemiology of respiratory viral infections in hematopoietic cell transplant recipients and solid organ transplant recipients,” Current Opinion in Infectious Diseases, vol. 24, no. 4, pp. 333–343, 2011. View at Publisher · View at Google Scholar · View at Scopus
  6. O. Ruuskanen, E. Lahti, L. C. Jennings, and D. R. Murdoch, “Viral pneumonia,” The Lancet, vol. 377, no. 9773, pp. 1264–1275, 2011. View at Publisher · View at Google Scholar · View at Scopus
  7. S. Sethi, “Molecular diagnosis of respiratory tract infection in acute exacerbations of chronic obstructive pulmonary disease,” Clinical Infectious Diseases, vol. 52, no. 4, pp. S290–S295, 2011. View at Publisher · View at Google Scholar · View at Scopus
  8. P. Gao, J. Zhang, X. He, Y. Hao, K. Wang, and P. G. Gibson, “Sputum inflammatory cell-based classification of patients with acute exacerbation of chronic obstructive pulmonary disease,” PLoS ONE, vol. 8, no. 5, Article ID e57678, 2013. View at Publisher · View at Google Scholar · View at Scopus
  9. S. D. Aaron, J. B. Angel, M. Lunau et al., “Granulocyte inflammatory markers and airway infection during acute exacerbation of chronic obstructive pulmonary disease,” American Journal of Respiratory and Critical Care Medicine, vol. 163, no. 2, pp. 349–355, 2001. View at Publisher · View at Google Scholar · View at Scopus
  10. C. Moermans, V. Heinen, M. Nguyen et al., “Local and systemic cellular inflammation and cytokine release in chronic obstructive pulmonary disease,” Cytokine, vol. 56, no. 2, pp. 298–304, 2011. View at Publisher · View at Google Scholar · View at Scopus
  11. L. Dong, J.-W. Xia, Y. Gong et al., “Effect of lianhuaqingwen capsules on airway inflammation in patients with acute exacerbation of chronic obstructive pulmonary disease,” Evidence-Based Complementary and Alternative Medicine, vol. 2014, Article ID 637969, 11 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  12. J. Vestbo, S. S. Hurd, A. G. Agustí et al., “Global strategy for the diagnosis, management, and prevention of chronic obstructive pulmonary disease: GOLD executive summary,” American Journal of Respiratory and Critical Care Medicine, vol. 187, no. 4, pp. 347–365, 2013. View at Publisher · View at Google Scholar · View at Scopus
  13. T. A. R. Seemungal, G. C. Donaldson, E. A. Paul, J. C. Bestall, D. J. Jeffries, and J. A. Wedzicha, “Effect of exacerbation on quality of life in patients with chronic obstructive pulmonary disease,” American Journal of Respiratory and Critical Care Medicine, vol. 157, no. 5, pp. 1418–1422, 1998. View at Publisher · View at Google Scholar · View at Scopus
  14. I. S. Patel, T. A. R. Seemungal, M. Wilks, S. J. Lloyd-Owen, G. C. Donaldson, and J. A. Wedzicha, “Relationship between bacterial colonisation and the frequency, character, and severity of COPD exacerbations,” Thorax, vol. 57, no. 9, pp. 759–764, 2002. View at Publisher · View at Google Scholar · View at Scopus
  15. P. Gao, P. G. Gibson, J. Zhang et al., “The safety of sputum induction in adults with acute exacerbation of COPD,” Clinical Respiratory Journal, vol. 7, no. 1, pp. 101–109, 2013. View at Publisher · View at Google Scholar · View at Scopus
  16. E. Biancardi, M. Fennell, W. Rawlinson, and P. S. Thomas, “Viruses are frequently present as the infecting agent in acute exacerbations of chronic obstructive pulmonary disease in patients presenting to hospital,” Internal Medicine Journal, vol. 46, no. 10, pp. 1160–1165, 2016. View at Publisher · View at Google Scholar
  17. F. W. S. Ko, M. Ip, P. K. S. Chan et al., “Viral etiology of acute exacerbations of COPD in Hong Kong,” Chest, vol. 132, no. 3, pp. 900–908, 2007. View at Publisher · View at Google Scholar · View at Scopus
  18. A. F. Hutchinson, A. K. Ghimire, M. A. Thompson et al., “A community-based, time-matched, case-control study of respiratory viruses and exacerbations of COPD,” Respiratory Medicine, vol. 101, no. 12, pp. 2472–2481, 2007. View at Publisher · View at Google Scholar · View at Scopus
  19. C. A. Camargo Jr., A. A. Ginde, S. Clark, C. P. Cartwright, A. R. Falsey, and D. E. Niewoehner, “Viral pathogens in acute exacerbations of chronic obstructive pulmonary disease,” Internal and Emergency Medicine, vol. 3, no. 4, pp. 355–359, 2008. View at Publisher · View at Google Scholar · View at Scopus
  20. J. D. Beckham, A. Cadena, J. Lin et al., “Respiratory viral infections in patients with chronic, obstructive pulmonary disease,” Journal of Infection, vol. 50, no. 4, pp. 322–330, 2005. View at Publisher · View at Google Scholar · View at Scopus
  21. L. Feng, A. W. Mounts, Y. Feng et al., “Seasonal influenza vaccine supply and target vaccinated population in China, 2004–2009,” Vaccine, vol. 28, no. 41, pp. 6778–6782, 2010. View at Publisher · View at Google Scholar · View at Scopus
  22. M.-Y. Dai, J.-P. Qiao, Y.-H. Xu, and G.-H. Fei, “Respiratory infectious phenotypes in acute exacerbation of COPD: an aid to length of stay and COPD assessment test,” International Journal of COPD, vol. 10, no. 1, pp. 2257–2263, 2015. View at Publisher · View at Google Scholar · View at Scopus
  23. A. R. Falsey, P. A. Hennessey, M. A. Formica, C. Cox, and E. E. Walsh, “Respiratory syncytial virus infection in elderly and high-risk adults,” The New England Journal of Medicine, vol. 352, no. 17, pp. 1749–1759, 2005. View at Publisher · View at Google Scholar · View at Scopus
  24. W. A. R. Zwaans, P. Mallia, M. E. C. van Winden, and G. G. U. Rohde, “The relevance of respiratory viral infections in the exacerbations of chronic obstructive pulmonary disease—a systematic review,” Journal of Clinical Virology, vol. 61, no. 2, pp. 181–188, 2014. View at Publisher · View at Google Scholar · View at Scopus
  25. A. S. Monto, T. J. Bramley, and M. Sarnes, “Development of a predictive index for picornavirus infections,” Clinical Infectious Diseases, vol. 36, no. 3, pp. 253–258, 2003. View at Publisher · View at Google Scholar · View at Scopus
  26. A. F. Hutchinson, J. Black, M. A. Thompson et al., “Identifying viral infections in vaccinated chronic obstructive pulmonary disease (COPD) patients using clinical features and inflammatory markers,” Influenza and other Respiratory Viruses, vol. 4, no. 1, pp. 33–39, 2010. View at Publisher · View at Google Scholar · View at Scopus
  27. J. R. Hurst, G. C. Donaldson, W. R. Perera et al., “Use of plasma biomarkers at exacerbation of chronic obstructive pulmonary disease,” American Journal of Respiratory and Critical Care Medicine, vol. 174, no. 8, pp. 867–874, 2006. View at Publisher · View at Google Scholar · View at Scopus
  28. P. R. Waldron, I. Belitskaya-Lévy, A. Chary et al., “Genetic variation in the IL-6 and HLA-DQB1 genes is associated with spontaneous clearance of hepatitis C virus infection,” Journal of Immunology Research, vol. 2016, Article ID 6530436, 9 pages, 2016. View at Publisher · View at Google Scholar · View at Scopus
  29. G. Rohde, I. Borg, A. Wiethege et al., “Inflammatory response in acute viral exacerbations of COPD,” Infection, vol. 36, no. 5, pp. 427–433, 2008. View at Publisher · View at Google Scholar · View at Scopus
  30. R. Almansa, L. Socias, D. Andaluz-Ojeda et al., “Viral infection is associated with an increased proinflammatory response in chronic obstructive pulmonary disease,” Viral Immunology, vol. 25, no. 4, pp. 249–253, 2012. View at Publisher · View at Google Scholar · View at Scopus
  31. R. M. Strieter, J. A. Belperio, and M. P. Keane, “Host innate defenses in the lung: the role of cytokines,” Current Opinion in Infectious Diseases, vol. 16, no. 3, pp. 193–198, 2003. View at Publisher · View at Google Scholar · View at Scopus
  32. S. Pant, E. H. Walters, A. Griffiths, R. Wood-Baker, D. P. Johns, and D. W. Reid, “Airway inflammation and anti-protease defences rapidly improve during treatment of an acute exacerbation of COPD,” Respirology, vol. 14, no. 4, pp. 495–503, 2009. View at Publisher · View at Google Scholar · View at Scopus
  33. I. Sabroe, C. M. Lloyd, M. K. B. Whyte, S. K. Dower, T. J. Williams, and J. E. Pease, “Chemokines, innate and adaptive immunity, and respiratory disease,” European Respiratory Journal, vol. 19, no. 2, pp. 350–355, 2002. View at Publisher · View at Google Scholar · View at Scopus
  34. K. Fjeldborg, S. B. Pedersen, H. J. Møller, T. Christiansen, M. Bennetzen, and B. Richelsen, “Human adipose tissue macrophages are enhanced but changed to an anti-inflammatory profile in obesity,” Journal of Immunology Research, vol. 2014, Article ID 309548, 10 pages, 2014. View at Publisher · View at Google Scholar · View at Scopus
  35. M. J. Cameron, J. F. Bermejo-Martin, A. Danesh, M. P. Muller, and D. J. Kelvin, “Human immunopathogenesis of severe acute respiratory syndrome (SARS),” Virus Research, vol. 133, no. 1, pp. 13–19, 2008. View at Publisher · View at Google Scholar · View at Scopus
  36. N. Lee, C. K. Wong, P. K. S. Chan et al., “Cytokine response patterns in severe pandemic 2009 h1n1 and seasonal influenza among hospitalized adults,” PLoS ONE, vol. 6, no. 10, 2011. View at Publisher · View at Google Scholar · View at Scopus
  37. K. Pappas, A. I. Papaioannou, K. Kostikas, and N. Tzanakis, “The role of macrophages in obstructive airways disease: chronic obstructive pulmonary disease and asthma,” Cytokine, vol. 64, no. 3, pp. 613–625, 2013. View at Publisher · View at Google Scholar · View at Scopus
  38. J. P. Wong, M. E. Christopher, S. Viswanathan et al., “Activation of toll-like receptor signaling pathway for protection against influenza virus infection,” Vaccine, vol. 27, no. 25-26, pp. 3481–3483, 2009. View at Publisher · View at Google Scholar · View at Scopus
  39. Y. Yageta, Y. Ishii, Y. Morishima et al., “Role of Nrf2 in host defense against influenza virus in cigarette smoke-exposed mice,” Journal of Virology, vol. 85, pp. 4679–4690, 2011. View at Google Scholar
  40. H. Sprenger, R. G. Meyer, A. Kaufmann, D. Bußfeld, E. Rischkowsky, and D. Gemsa, “Selective induction of monocyte and not neutrophil-attracting chemokines after influenza A virus infection,” Journal of Experimental Medicine, vol. 184, no. 3, pp. 1191–1196, 1996. View at Publisher · View at Google Scholar · View at Scopus
  41. T. Ronni, S. Matikainen, T. Sareneva et al., “Regulation of IFN-α/β, MxA, 2′,5′-oligoadenylate synthetase, and HLA gene expression in influenza A-infected human lung epithelial cells,” Journal of Immunology, vol. 158, no. 5, pp. 2363–2374, 1997. View at Google Scholar · View at Scopus
  42. D. Bußfeld, A. Kaufmann, R. G. Meyer, D. Gemsa, and H. Sprenger, “Differential mononuclear leukocyte attracting chemokine production after stimulation with active and inactivated influenza A virus,” Cellular Immunology, vol. 186, no. 1, pp. 1–7, 1998. View at Publisher · View at Google Scholar · View at Scopus
  43. T. Sareneva, S. Matikainen, M. Kurimoto, and I. Julkunen, “Influenza A virus-induced IFN-α/β and IL-18 synergistically enhance IFN-γ gene expression in human T cells,” Journal of Immunology, vol. 160, no. 12, pp. 6032–6038, 1998. View at Google Scholar · View at Scopus
  44. I. Julkunen, T. Sareneva, J. Pirhonen, T. Ronni, K. Melén, and S. Matikainen, “Molecular pathogenesis of influenza A virus infection and virus-induced regulation of cytokine gene expression,” Cytokine and Growth Factor Reviews, vol. 12, no. 2-3, pp. 171–180, 2001. View at Publisher · View at Google Scholar · View at Scopus