Impact of the Polymorphism rs9264942 near the HLA-C Gene on HIV-1 DNA Reservoirs in Asymptomatic Chronically Infected Patients Initiating Antiviral Therapy

Table 2

Frequencies of the genotypes for the SNP rs9264942 in the HLA-C 5 region, where T is the major allele and C is the minor allele. HIV-1 RNA and HIV-1 DNA levels are shown in the patients naïve for antiretroviral therapy (pre-ART), one month (1 m) post-ART, and at the end of the study (follow-up: 36 months).

rs9264942 genotypes		Frequency N (%)	HIV-1 RNA, median (min–max)			HIV-1 DNA, median (min–max)
			Pre-ART	1 m post-ART	End of study	Pre-ART	1 m post-ART	End of study
Total	TT	54 (29.5%)	24,976 (200–460,000)	200 (200–60,000)	5400 (200–56,543)	927.5 (250–32,560)	1080 (250–10,645)	250 (250–2570)
	CT	95 (51.9%)	11,450 (200–274,500)	200 (200–25,000)	1125 (200–46,200)	520.0 (250–12,985)	440 (250–18,855)	250 (250–10,120)
	CC	34 (18.6%)	9250 (200–206,500)	200 (200–16,100)	5252 (200–41,200)	448.5 (250–17,425)	420 (250–7475)	250 (250–930)
			N.S.	N.S.	N.S.			N.S.

Median and minimum–maximum values of viremia and cellular-associated viral loads are indicated for the respective genotypes, HIV-1 RNA in copies/mL, and HIV-1 DNA in copies/10⁶ PBMCs. The values are for median comparisons; N.S.: not significant.