Impact of the Polymorphism rs9264942 near the HLA-C Gene on HIV-1 DNA Reservoirs in Asymptomatic Chronically Infected Patients Initiating Antiviral Therapy

Table 4

Cox regression model for the virological failure during antiviral therapy.

Variable	HR (95% CI)	Endpoint p (%)
HIV-1 RNA (log10 copies/mL)^a	1.86 (1.27–2.72)	65.5	0.001
HIV-1 DNA (log10 copies/10^6 PBMC)^a	1.74 (1.10–2.77)	63.0	0.018
Protective allele −35 C^b	0.90 (0.54–1.50)	47.3	0.698

Cox regression model for the virological failure according to the presence of the protective allele −35 C for the SNP rs9264942 adjusting for HIV-1 RNA levels and HIV-1 DNA levels. Hazard ratio (HR), 95% confidence intervals (CIs), endpoint p (probability to reach an endpoint, as defined by HR/(1 + HR)), and values are shown. ^aHRs calculated for a 1-log₁₀ increased. ^bHR calculated for the allele −35 C as a categorical variable (presence of the allele −35 C for the SNP rs9264942[T > C]).