Gene Expression Profiles of Human Phosphotyrosine Phosphatases Consequent to Th1 Polarisation and Effector Function

Table 1

Class-I classical RPTP and NRPTP included in this study.

Phosphatase	Substrate	Regulation of T cell activation	Involved in autoimmunity	References
PTPRA (RPTPα)	SFK	Regulation of TCR signalling:	Not reported	[15]
PTPRC (CD45)	SFK and JAK family kinases	Regulation of TCR and cytokine signalling	MS, AH	[13, 16, 17]
PTPRJ (CD148)	SFK	Regulation of TCR signalling	Not reported	[18, 19]
PTPRK (RPTPκ)	STAT3	Regulation of CD4 T cell development	Not reported	[20, 21]
PTPN1 (PTP1B)	STAT6	Not reported	Not reported	[22]
PTPN2 (TC-PTP)	SFK, JAK1, JAK3	Regulation of TCR and cytokine signalling	T1D, CD, S	[23–26]
PTPN4 (PTP-MEG1)	CD247	Regulation of TCR signalling	Not reported	[27]
PTPN6 (SHP1)	SFK, ITAMs, ZAP70, SLP-76	Regulation of TCR signalling	PS	[28, 29]
PTPN7 (HePTP)	ERK1/2, p38	Regulation of TCR signalling	Not reported	[30, 31]
PTPN9 (PTP-MEG2)	NSF	Regulation of cytokine secretion	Not reported	[32, 33]
PTPN12 (PTP-PEST)	Pyk2	Positive regulator of secondary T cell responses	Not reported	[34]
PTPN13 (PTP-BAS)	STAT4, STAT6	Regulation of cytokine signalling	Not reported	[35]
PTPN18 (PTP20)	HER2	Not reported	Not reported	[36]
PTPN22 (LYP)	ZAP70, LCK, FYN	Regulation of TCR signalling	T1D, RA, SLE	[37–39]

SFK: Src family kinases, MS: multiple sclerosis, AH: autoimmune hepatitis, T1D: type 1 diabetes, CD: Crohn’s disease, S: synovitis, PS: psoriasis, RA: rheumatoid arthritis, and SLE: systemic lupus erythematosus.