Clinical Features and Genetic Analysis of 48 Patients with Chronic Granulomatous Disease in a Single Center Study from Shanghai, China (2005–2015): New Studies and a Literature Review

Table 2

Summary of infections in CGD patients from 4 major PID centers in Mainland China and 2 large cohort studies from other countries.

Infections	This study	Center 2	Center 3	Center 4	USA [10]	Europe [11]
	(%)	(%)	(%)	(%)	(%)	(%)
Lung	37 (77%)	—	44 (92%)	41 (98%)	—	284 (66%)
Pneumonia	35 (73%)	32 (84%)	44 (92%)	34 (81%)	290 (79%)	—
Lung abscess	0	—	4 (8%)	1 (2%)	60 (16%)	24 (6%)
Tuberculosis	7 (15%)	21 (55%)	⩾10 (21%)	6 (14%)	—	—
GI tract	26 (54%)	—	—	17 (40%)	—	208 (48%)
Diarrhea/enteritis	15 (31%)	14 (37%)	31 (65%)	7 (17%)	—	55 (13%)
Perianal abscess	18 (38%)	—	13 (28%)	9 (21%)	57 (15%)	88 (21%)
Liver abscess	4 (8%)	—	≥3 (6%)	1 (2 %)	98 (27%)	138 (32%)
Cutaneous/subcutaneous infections	22 (46%)	—	22 (46%)	17 (40%)	156 (42%)	229 (53%)
Pustular eruption	10 (21%)	—	9 (19%)	9 (21%)	—	—
Skin abscess	11 (23%)	16 (42%)	11 (23%)	2 (5%)	—	74 (17%)
Lymphadenitis	24 (50%)	16 (42%)	31 (65%)	26 (62%)	194 (53%)	213 (50%)
Septicopyemia	11 (23%)	—	—	16 (38%)	65 (18%)	85 (20%)
UTI	1 (2%)	—	3 (6%)	1 (2%)		52 (12%)
Bone	2 (4%)	—	2 (4%)	0		56 (13%)
Osteomyelitis	1 (2%)	—	1 (2%)	0	90 (25%)	56 (13%)
Bone tuberculosis	1 (2%)	—	1 (2%)	0	—	—
CNS	2 (4%)	—	—	6 (14%)	—	—
Meningitis	1 (2%)	—	—	5 (12%)	15 (4%)	—
Brain abscess	0	—	—	1 (2%)	12 (3%)	31 (7%)
Autoimmunity-; rheumatology	3 (6%)	—	—	—	18 (5%)	26 (6%)

GI: gastrointestinal; UTI: urinary tract infection; CNS: central nervous system.
38 patients from center 2 were reviewed from 1 paper published in English version [15].
48 patients from center 3 were reviewed from 1 paper published in English version and 1 in Chinese version [16, 20].
42 patients from center 4 were reviewed from 10 papers published in Chinese version [21–30].