Clinical Features and Genetic Analysis of 48 Patients with Chronic Granulomatous Disease in a Single Center Study from Shanghai, China (2005–2015): New Studies and a Literature Review

Table 6

Comparison of different subtypes of CGD in 4 major PID centers from Mainland China and large cohort studies from other countries.

Pts	XL-CGD	AR-CGD			UD	Total
	CYBB	CYBA	NCF1	NCF2
This study	36/48; (75%)	1/48; (2%)	1/48; (2%)	1/48; (2%)	9/48; (19%)	48
Center 2 [15]	30/38; (79%)	2/48; (5%)	3/48; (8%)	0/48; (0%)	3/48; (8%)	38
Center 3 [16, 20]	31/48; (65%)	1/48; (2%)	2/48; (4%)	3/48; (6%)	11/48; (23%)	48
Center 4 [21–30]	36/42; (86%)	2/42; (5%)	1/42; (2%)	0/42; (0%)	3/42; (7%)	42
Japan [12]	109/148; (74%)	16/148; (11%)	10/148; (7%)	13/148; (9%)	—	229
The United States [10]	259/368; (70%)	7/368; (2%)	45/368; (12%)	10/368; (3%)	28/368; (8%)	368
Europe [11]	290/429; (68%)	22/429; (5%)	69/429; (16 %)	11/429; (3%)	37/429; (9%)	429
Turkey [32]	34/89; (38%)	20/89; (23%)	17/89; (19%)	13/89; (15%)	5/89; (6%)	89

Pts: patients; XL: X-linked; AR: autosomal recessive; UD: unidentified.
A total of 229 CGD patients were reported in a Japanese national registry, 148 of whom have been classified into four types based on flow cytometric and western blotting analysis.