Neuroprotective Potential of Gentongping in Rat Model of Cervical Spondylotic Radiculopathy Targeting PPAR-γ Pathway

Figure 8

Schematic diagram depicting how GTP modulates the PPAR-γ pathway to play a neuroprotection role in CSR. As indicated, arachidic acid is the common component of Radix Puerariae and Carthamus tinctorius. By directly activating PPAR-γ, GTP could inhibit inflammation and apoptosis by decreasing TNF-α and Bax and increasing Bcl-2, respectively. Meanwhile, by aggrandizing NF200, GTP could improve the cytoskeletal integrity.