Getting “Inside” Type I IFNs: Type I IFNs in Intracellular Bacterial Infections

Figure 1

Induction of type I IFNs by intracellular bacteria. Type I IFNs can be induced via cytosolic nucleic acid sensors RIG-I, MDA5, RNA Pol III, cGAS, and STING or nucleic acid-sensing TLR3, 7 or 9. Bacterial products like LPS and MDP can signal the production of type I IFNs via TLR4 or NOD2/RIP2, respectively.